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Original Article
ARTICLE IN PRESS
doi:
10.25259/AUJMSR_88_2025

Post operative knee stiffness after surgical fixation of knee osseous injuries

Department of Orthopedics, Makerere University Kampala, Kampala, Uganda.
Department of Orthopedics, Mulago National Referral Hospital, Kampala, Uganda.
Author image

*Corresponding author: Oitangor Arthur, Department of Orthopedics, Makerere University Kampala, Kampala, Uganda. aoitangor@gmail.com

Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Arthur O, Yasin S, Phillip M. Post operative knee stiffness after surgical fixation of knee osseous injuries. Adesh Univ J Med Sci Res. doi: 10.25259/AUJMSR_88_2025

Abstract

Objectives:

The objective of this study was to establish the severity of post-operative knee stiffness and associated factors after surgical fixation of knee osseous injuries among adults at Mulago National Referral Hospital.

Material and Methods:

A cross-sectional study on 115 patients conducted at the orthopedic outpatient clinic of Mulago National Referral Hospital. The Del Pizzo classification was used to classify the severity of post-operative knee stiffness. Ordinal logistic regression was used for statistical analysis.

Results:

A large proportion (78.3%) exhibited varying severities of post-operative knee stiffness. About 43.3% had extension limitations, 16.7% had flexion limitations, and 40% had combined limitations. Non-adherence to physiotherapy, cigarette use, and surgical fixation performed 2 weeks after injury were significant.

Conclusion:

Severe and extreme grades were the most common; non-adherence to physiotherapy, delayed surgery, and cigarette use were independent predictors.

Keywords

Adherence
Knee osseous injuries
Severity
Surgical fixation

INTRODUCTION

It is observed that following surgical fixation of knee osseous injuries, patients may develop varying degrees of post-operative knee stiffness (POKS). The influence of POKS on an individual’s function is worse in the knee joint when compared to the ankle, elbow, and wrist joints.[1] For instance, good function is observed in the stiffness of the ankle and wrist, yet in the knee joint, post-operative stiffness affects the occupational, daily, and leisure activities more negatively. This influence depends on the degree of POKS.[1,2]

Furthermore, controversies in the literature exist on the association between several factors with the severity of POKS.[1,3,4] For example, Bishop et al. showed an association between time from injury to surgery with the severity of POKS,[1] a finding that was disputed by Wang et al.[4]

The lack of knowledge on POKS and its associated factors hinders its identification, complicates its treatment and rehabilitation, and, at the same time, impairs the patient’s ability to perform activities of daily living, thus affecting their quality of life.

Therefore, against this background, this study aimed at assessing the severity of POKS after surgical fixation of knee osseous injuries and evaluating its associated factors; our findings may be useful in the identification, prevention, and rehabilitation of POKS.

MATERIAL AND METHODS

This hospital-based cross-sectional study was conducted for 6 months among 115 patients.

Inclusion criteria

Any patient ≥18 years of age who was treated for knee osseous injuries by surgical fixation and had completed at least 6 months and not exceeding 2 years after surgical fixation, and consented to the study.

Exclusion criteria

Patients who had other osseous injuries in the ipsilateral lower limb that were not around the knee, and patients who had pathological osseous injuries around the knee.

Sample size estimation

To describe the severity of POKS following surgical fixation of knee osseous injuries among adults, the formula by Kish Leslie was utilized for this objective. This helped to describe the proportions of the severity of POKS and to establish the factors associated with knee stiffness following surgical fixation of knee osseous injuries among adults. The Fleiss formula was used. Therefore, the study enrolled 115 participants since it was the larger of the two calculated sample sizes.

Sampling procedure

Consecutive sampling was used because the sample size was finite and the estimated time frame of the study was short; therefore, every subject meeting the inclusion criteria was selected until the required sample size was achieved.

Data collection

Data were collected through physical examinations, interviews, and knee motion, which were measured using a GemRed digital goniometer. Data on independent variables were collected through face-to-face structured interviews, which included the socio-demographic and injury-related factors. The Principal Investigator measured POKS severity using a precise digital 12-inch GemRed goniometer, recording flexion and extension losses, including combined limitations when patients could not fully bend or straighten the knee.

Statistical analysis

Data were reviewed for completeness and accuracy and analyzed using STATA version 15. Descriptive statistics were used to summarize participant characteristics. Severity of POKS was categorized into normal, mild, moderate, severe, and extreme. Ordinal logistic regression was applied since the outcome variable was ordered. Variables with P < 0.2 at the bivariate level were included in the multivariate model. Statistical significance at the multivariate level was set at P < 0.05.

RESULTS

Of the 115 patients, 90 had varying degrees of POKS, with severe and extreme cases being the most common [Table 1]. Severe POKS was the median severity category. Flexion limitation was present in 39 (43.3%) patients, extension limitation was present in 15 (16.7%), and combined limitations were present in 36 (40%) patients. For distal femur fractures, 34 patients had flexion limitations, four had extension limitations, and three had combined limitations.

Table 1: Proportion of severity of POKS among the study participants.
Severity of POKS Total number Proportion (%) 95% CI
Normal active ROM 25 21.7 15.0–29.1
Mild POKS 6 5.2 2.3–8.1
Moderate POKS 22 19.1 12.9–22.5
Severe POKS 33 28.7 23.2–30.7
Extreme POKS 29 25.2 19.9–28.1

POKS: Post-operative knee stiffness, ROM: Range of motion, CI: Confidence interval

For proximal tibia fractures, 19 patients had extension limitations and 17 patients had flexion limitations. Twelve patients with patella fractures presented with extension limitation as opposed to flexion and combined limitations. For combined lower limb injuries, two patients had limitations in extension and flexion, and seven had combined limitations.

At bivariate ordinal logistic analysis, the factors that were significant included: Age (years), using external fixators and K-wires/cerclage as the type of implant, cigarette use, time from injury to surgery, and adherence to physiotherapy [Table 2]. At multiple ordinal logistic regression, adherence to physiotherapy, cigarette use, and time from injury to surgery >2 weeks were statistically significant [Table 3].

Table 2: Bivariate analysis.
Variable cOR P-value 95% CI
Age
  18–39 years 1
  40–59 years 0.18 0.021 0.087–0.894
  ≥60 years 0.27 0.042 0.067–0.715
Type of implant used
  IMN 1
  Ex fix 0.11 0.074 0.105–0.778
  Plate and screws 0.66 0.31 0.199–1.039
  Cerclage/wires 0.2 0.012 0.072–0.574
Cigarette use
  No 1
  Yes 1.28 0.152 0.758–3.757
Time from injury to surgery
  0–2 weeks 1
  >2 weeks 1.39 0.145 0.800–2.976
Adherence to physiotherapy
  No 1
  Yes 0.54 0.142 0.174–1.168

IMN: Intramedullary nail, CI: Confidence interval, cOR: Cumulative odds ratio. At bivariate, significant Pvalue was p<0.02, Ordinal Logistic regression was used and measure of association was cumulative Odds ratio. Ex fix: External fixation.

Table 3: Multivariate analysis.
Variable cOR P-value 95% CI
Adherence to physiotherapy
  No 1
  Yes 0.28 P<0.0001 0.16–0.49
Cigarette use
  No 1
  Yes 3.49 0.018 1.29–10.92
Time from injury to surgery
  0–2 weeks 1
  >2 weeks 1.35 0.036 1.02–7.76

CI: Confidence interval, Significant P- value was P<0.05, and the test was likelihood ratio test, cOR: Cumulative odds ratio.

DISCUSSION

POKS is a well-recognized complication following surgical fixation of knee osseous injuries.[2,5,6] In this study, 78.3% of the patients assessed between 6 months and 2 years after surgery exhibited varying degrees of POKS. The functional impact of POKS is directly related to its severity, and as highlighted by Robertson et al.,[7] the functional consequences of POKS also depend on patient activity levels.[8] The similarities in the distribution and severity of POKS found in this study align with findings from other research, such as that by Wang et al.,[4] and Mangone.[6] This may be attributed to multiple factors, including variations in surgical techniques and the surgeon’s experience.

The type of movement limitation observed varied by fracture location. Flexion limitations were more common in distal femur fractures, while extension limitations were frequent in proximal tibia and patella fractures. These findings align with previous studies by Lara et al.[9] and Vaish et al.[10] and may be influenced by surgical techniques and implant types.

For example, retrograde nails are associated with posterior angulation and flexion deficits, while plating systems such as distal femur locked plates allow for better control of joint alignment.[11,12] Conflicting findings in a study by Xing et al.[13] reported different outcomes in patella fractures, may be due to smaller sample sizes or different fixation methods.

This study found that adherence to physiotherapy significantly reduced the severity of POKS, with adherent patients being 72% less likely to fall into higher severity categories. These results are consistent with previous studies by Kumar et al.,[2] Sharma et al.,[14] and Ono et al.[15] which highlighted that physiotherapy supports joint mobility by promoting collagen remodeling, regulating inflammation, reducing pain sensitization, and preventing disuse.

Cigarette use was significantly associated with increased severity of POKS, with smokers being 3 times more likely to develop higher severity categories. This aligns with findings by Lara et al.[9] Cigarette smoking contributes to POKS severity through multiple mechanisms, including reduced tissue oxygenation due to vasoconstriction[16] heightened systemic inflammation promoting fibrosis,[17] and impaired cellular healing responses. In addition, smokers often exhibit lower adherence to physiotherapy, compounding the risk of joint stiffness.[18] The study also found that patients who underwent surgical fixation more than 2 weeks after injury were significantly more likely to develop severe POKS. The delay increases the risk of fibrosis, inflammation, and joint contractures, limiting mobility. While literature on the timing of surgery is mixed, differences in study definitions and surgical techniques likely explain inconsistencies.[10,11,17]

To ensure accuracy and consistency, a standard digital goniometer was used for measuring knee joint range of motion, with all measurements conducted by the Principal Investigator to reduce variability. Research assistants underwent pre-study training covering recruitment procedures, data collection, and consent processes to standardize assessments. This study had limitations, as a cross-sectional design, it could not establish causality and was prone to recall bias due to reliance on self-reported data, and it did not account for the severity of the initial injury, which likely influenced POKS outcomes.

CONCLUSION

This study revealed a substantial variation in the severity of POKS among adults following surgical fixation of knee osseous injuries, and a notable proportion of patients experienced severe or extreme grades of POKS. Three factors were identified as independent predictors for the development of severe or extreme POKS, namely, non-adherence to prescribed physiotherapy protocols, delayed surgical fixation, defined as surgery performed more than 2 weeks post-injury, and cigarette smoking.

Targeted interventions addressing these risk factors may play a role in improving post-operative recovery and long-term joint function.

Acknowledgment:

We would like to extend our appreciation to the entire staff that we worked with on this research project.

Authors’ contributions:

OA: Conceived the study and was responsible for the conceptualization and design of the research. He defined the intellectual content, conducted the literature search, performed data acquisition, carried out data analysis and statistical analysis, and prepared the manuscript. He drafted the initial version of the manuscript, approved the final version for submission, and agrees to be accountable for all aspects of the work; SY: Contributed to the design of the study, supported the definition of intellectual content, assisted in the data analysis, and critically revised the manuscript for important intellectual content; MP: Contributed to the concepts, supported the manuscript preparation, and reviewed the manuscript writing for accuracy and clarity. All authors approved the final version for submission, and they give the rights to the corresponding author (Oitangor Arthur) to make necessary changes as per the request of the journal, do the rest of the correspondence on our behalf, and he will act as the guarantor for the manuscript on our behalf.

Ethical approval:

The research/study was approved by the Institutional Review Board at Makerere University School of Medicine Research Ethics Committee, number MaK-SOMREC-2024-979, dated 19th September 2024.

Declaration of patient consent:

The authors certify that they have obtained all appropriate patient consent.

Conflicts of interest:

There are no conflicts of interest.

Use of artificial intelligence (AI)-assisted technology for manuscript preparation:

The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the writing or editing of the manuscript, and no images were manipulated using AI.

Financial support and sponsorship: Nil.

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